Stem cells are unique cells with amazing healing capabilities, but it has only been in the last decade that a substantial number of scientists are finally investigating and providing insights on how to use them most effectively.
This new direction is also supported with the help of clinicians having “boots on the ground” who are actually witnessing and documenting the effects and what they’re capable of. As well there is great and continued interest and research into what concurrent therapies or interventions might increase the stem cells ability to work their magic.
Here is where exosomes come on to the stage. Science has recently discovered what actually happens when the endogenous stem cells are deployed in a body joint, or spine through stem cell treatment.
It appears that it is the presence of the stem cells that are most important, not just the idea that they only repair damage, but it has become increasingly clear that they have a unique signaling system, the “paracrine effect”. This effect describes the cell-to-cell communication that goes on once the stem cells are implanted.
One of the most important ‘talking’, or signaling messenger molecules, are the exosomes which are excreted from the stem cells into the surrounding cells and tissues, encouraging them to repair and regenerate.
Through a complicated process of angiogenesis (formation of new blood vessels) and tissue renewal, this paracrine effect appears to be able to greatly improve the promotion of the stem cells in their repair and rebuilding function.
Although exosomes were discovered over five decades ago, interest among the scientific community didn’t pique until much later. Specifically, in the last ten years, the number of annual publications about exosomes have almost increased by tenfold (from 1,570 published papers in 2007 to 14,000 in 2017).
Recent studies have shown that this is an area of regenerative medicine worth keeping an eye on as it continues to develop.
Original blog piece was written by Dr. Bean of MyStemCell.com and reproduced with permission.